Improved split prime editors enable efficient in vivo genome editing

Summary: Efficient prime editor (PE) delivery in vivo is critical for realizing its full potential in disease modeling and therapeutic correction. Although PE has been divided into two halves and delivered using dual adeno-associated viruses (AAVs), the editing efficiency at different gene loci vari...

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Bibliographic Details

Published in:	Cell Reports
Main Authors:	Rongwei Wei, Zhenxing Yu, Lihong Ding, Zhike Lu, Keyi Yao, Heng Zhang, Binglin Huang, Miao He, Lijia Ma
Format:	Article
Language:	English
Published:	Elsevier 2025-01-01
Subjects:	CP: Genomics
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124724014955