P-Rex2 suppresses glucose uptake into liver and skeletal muscle through different adaptor functions

Abstract P-Rex2 is a Rac guanine-nucleotide factor (Rac-GEF) that controls glucose homeostasis. This role is thought to be mediated through its adaptor function inhibiting Pten rather than through its Rac-GEF activity, but this remains to be demonstrated. To examine this question, we have investigat...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Elpida Tsonou, Julia Y. Chu, Polly A. Machin, Anna G. Roberts, Anne Segonds-Pichon, David Baker, David C. Hornigold, Heidi C. E. Welch
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-08-01
Subjects:	P-Rex2 P-Rex1 Guanine-nucleotide exchange factor (GEF) Glucose homeostasis Liver Skeletal muscle
Online Access:	https://doi.org/10.1038/s41598-025-01720-w