Integrated structural variation and point mutation signatures in cancer genomes using correlated topic models.

Mutation signatures in cancer genomes reflect endogenous and exogenous mutational processes, offering insights into tumour etiology, features for prognostic and biologic stratification and vulnerabilities to be exploited therapeutically. We present a novel machine learning formalism for improved sig...

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Bibliographic Details

Published in:	PLoS Computational Biology
Main Authors:	Tyler Funnell, Allen W Zhang, Diljot Grewal, Steven McKinney, Ali Bashashati, Yi Kan Wang, Sohrab P Shah
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2019-02-01
Online Access:	http://europepmc.org/articles/PMC6402697?pdf=render