T cell metabolic reprogramming in acute kidney injury and protection by glutamine blockade

T cells play an important role in acute kidney injury (AKI). Metabolic programming of T cells regulates their function, is a rapidly emerging field, and is unknown in AKI. We induced ischemic AKI in C57BL/6J mice and collected kidneys and spleens at multiple time points. T cells were isolated and an...

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Bibliographic Details

Published in:	JCI Insight
Main Authors:	Kyungho Lee, Elizabeth A. Thompson, Sepideh Gharaie, Chirag H. Patel, Johanna T. Kurzhagen, Phillip M. Pierorazio, Lois J. Arend, Ajit G. Thomas, Sanjeev Noel, Barbara S. Slusher, Hamid Rabb
Format:	Article
Language:	English
Published:	American Society for Clinical investigation 2023-06-01
Subjects:	Immunology Nephrology
Online Access:	https://doi.org/10.1172/jci.insight.160345