Asymmetric one-pot sequential Friedel–Crafts-type alkylation and α-oxyamination catalyzed by a peptide and an enzyme

In the presence of a peptide catalyst and the oxidative enzyme laccase, a one-pot sequential reaction including a Friedel–Crafts-type alkylation of α,β-unsaturated aldehydes followed by an α-oxyamination was realized. The reaction in aqueous solvent to promote the enzymatic oxidation, and the use of...

Full description

Bibliographic Details

Published in:	Beilstein Journal of Organic Chemistry
Main Authors:	Kengo Akagawa, Ryota Umezawa, Kazuaki Kudo
Format:	Article
Language:	English
Published:	Beilstein-Institut 2012-08-01
Subjects:	Friedel–Crafts-type alkylation laccase one-pot reaction organocatalysis α-oxyamination resin-supported peptide catalyst
Online Access:	https://doi.org/10.3762/bjoc.8.152