Δ133p53α and Δ160p53α isoforms of the tumor suppressor protein p53 exert dominant-negative effect primarily by co-aggregation

p53 is a tumor suppressor protein with multiple isoforms with shared or specific functions. However, two of its isoforms, Δ133p53α and Δ160p53α, with large N-terminal deletions, can cause cancer. These isoforms exert a dominant-negative effect on full-length p53 (FLp53), although the precise molecul...

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Bibliographic Details

Published in:	eLife
Main Authors:	Liuqun Zhao, Tanel Punga, Suparna Sanyal
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2025-07-01
Subjects:	p53 cancer apoptosis p53 isoform dominant-negative effect protein aggregation
Online Access:	https://elifesciences.org/articles/106469