Sigma-2 receptor modulator CT1812 alters key pathways and rescues retinal pigment epithelium (RPE) functional deficits associated with dry age-related macular degeneration (AMD)

Abstract Trafficking defects in retinal pigmented epithelial (RPE) cells contribute to RPE atrophy, a hallmark of geographic atrophy (GA) in dry age-related macular degeneration (AMD). Dry AMD pathogenesis is multifactorial, including amyloid-β (Aβ) accumulation and oxidative stress—common features...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Britney N. Lizama, Eloise Keeling, Eunah Cho, Evi M. Malagise, Nicole Knezovich, Lora Waybright, Emily Watto, Gary Look, Valentina Di Caro, Anthony O. Caggiano, J. Arjuna Ratnayaka, Mary E. Hamby
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-02-01
Online Access:	https://doi.org/10.1038/s41598-025-87921-9