Inflammatory abrasion of hematopoietic stem cells: a candidate clue for the post-CAR-T hematotoxicity?

Chimeric antigen receptor T-cell (CAR-T) therapy has shown remarkable effects in treating various hematological malignancies. However, hematotoxicity, specifically neutropenia, thrombocytopenia, and anemia, poses a serious threat to patient prognosis and remains a less focused adverse effect of CAR-...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Ting Sun, Dengju Li, Liang Huang, Xiaojian Zhu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-05-01
Subjects:	cytopenia hematotoxicity inflammation CAR-T hematopoietic stem cell
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1141779/full