Whole genome sequencing reveals novel resistance-conferring mutations and large genome deletions in drug-resistant Mycobacterium tuberculosis isolates from Indonesia

Objective: This study evaluated drug resistance profiles of Mycobacterium tuberculosis (Mtb) isolates in West Java, Indonesia through phenotypic and genomic approaches. Methods: We performed phenotypic drug-susceptibility testing (DST), coupled with whole-genome sequencing (WGS) of 142 Mtb isolates...

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Bibliographic Details

Published in:	Journal of Global Antimicrobial Resistance
Main Authors:	Htin Lin Aung, Lidya Chaidir, Dian Ayu Eka Pitaloka, Yugen Miyahara, Narender Kumar, Arto Yuwono Soeroto, Greg M Cook, Reinout van Crevel, Bachti Alisjahbana, Sharon J. Peacock, Philip C Hill
Format:	Article
Language:	English
Published:	Elsevier 2025-09-01
Subjects:	MDR-TB Whole genome sequencing Novel mutations GeneXpert Tuberculosis Indonesia
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213716525001729