Association Between Synovial NTN4 Expression and Pain Scores, and Its Effects on Fibroblasts and Sensory Neurons in End-Stage Knee Osteoarthritis

Osteoarthritis (OA) is a chronic joint disease marked by synovial inflammation, cartilage degradation, and persistent pain. Although Netrin-4 (NTN4) has been implicated in pain modulation in rheumatoid arthritis (RA), its role in OA pain remains less understood. Previous research has documented that...

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Bibliographic Details

Published in:	Cells
Main Authors:	Ayumi Tsukada, Yui Uekusa, Etsuro Ohta, Akito Hattori, Manabu Mukai, Dai Iwase, Jun Aikawa, Yoshihisa Ohashi, Gen Inoue, Masashi Takaso, Kentaro Uchida
Format:	Article
Language:	English
Published:	MDPI AG 2025-03-01
Subjects:	osteoarthritis netrin-4 synovium sensory neuron fibroblast
Online Access:	https://www.mdpi.com/2073-4409/14/6/395