Increased excitatory connectivity and epileptiform activity in thrombospondin1/2 knockout mice following cortical trauma

Thrombospondins (TSPs) are astrocyte-secreted extracellular matrix proteins that play key roles as regulators of synaptogenesis in the central nervous system. We previously showed that TSP1/2 are upregulated in the partial neocortical isolation model (“undercut” or “UC” below) of posttraumatic epile...

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Bibliographic Details

Published in:	Neurobiology of Disease
Main Authors:	Haifeng Shu, Isabel Parada, Alex Delgado, David A. Prince, Feng Gu
Format:	Article
Language:	English
Published:	Elsevier 2024-10-01
Subjects:	Thrombospondin Excitatory synapses Epilepsy Cortical injury
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996124002341