scRNA‐seq reveals NAMPT‐mediated macrophage polarization shapes smooth muscle cell plasticity in pulmonary arterial hypertension

Abstract Phenotypic switching of smooth muscle cells (SMC) is a crucial process in the pathogenesis of pulmonary arterial hypertension (PAH). However, the underlying mechanism is unclear. Here, we performed single‐cell RNA sequencing on pulmonary arteries obtained from lung transplantation to explor...

Full description

Bibliographic Details

Published in:	Interdisciplinary Medicine
Main Authors:	Zuoshi Wen, Liujun Jiang, Fangcong Yu, Xiaodong Xu, Mengjia Chen, Chenxi Li, Zhangquan Ying, Jianing Xue, Pengwei Zhu, Mairedan Muhetarijiang, Qingbo Xu, Zhoubin Li, Ting Chen
Format:	Article
Language:	English
Published:	Wiley-VCH 2024-10-01
Subjects:	macrophage polarization NAMPT phenotypic switching pulmonary arterial hypertension single‐cell RNA sequencing smooth muscle cell
Online Access:	https://doi.org/10.1002/INMD.20240016