Phase separation and pathologic transitions of RNP condensates in neurons: implications for amyotrophic lateral sclerosis, frontotemporal dementia and other neurodegenerative disorders

Liquid–liquid phase separation results in the formation of dynamic biomolecular condensates, also known as membrane-less organelles, that allow for the assembly of functional compartments and higher order structures within cells. Multivalent, reversible interactions between RNA-binding proteins (RBP...

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書誌詳細

出版年:	Frontiers in Molecular Neuroscience
主要な著者:	Aditi Naskar, Asima Nayak, Muthu Raj Salaikumaran, Sonali S. Vishal, Pallavi P. Gopal
フォーマット:	論文
言語:	英語
出版事項:	Frontiers Media S.A. 2023-09-01
主題:	neurodegenerative disease RNA-binding proteins aggregation phase separation biomolecular condensates
オンライン･アクセス:	https://www.frontiersin.org/articles/10.3389/fnmol.2023.1242925/full