The TMEM106B T186S coding variant increases neurite arborization and synaptic density in primary hippocampal neurons

The lysosomal protein TMEM106B was identified as a risk modifier of multiple dementias including frontotemporal dementia and Alzheimer’s disease. The gene comes in two major haplotypes, one associated with disease risk, and by comparison, the other with resilience. Only one coding polymorphism disti...

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Bibliographic Details

Published in:	Frontiers in Neuroscience
Main Authors:	Quynh Nguyen, Caleb A. Wood, Peter J. Kim, Joanna L. Jankowsky
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-10-01
Subjects:	TMEM106B T185S coding variant neuron development primary hippocampal neuron knock-out mouse
Online Access:	https://www.frontiersin.org/articles/10.3389/fnins.2023.1275959/full