Ribonuclease activity of Dis3 is required for mitotic progression and provides a possible link between heterochromatin and kinetochore function.

<h4>Background</h4>Cellular RNA metabolism has a broad range of functional aspects in cell growth and division, but its role in chromosome segregation during mitosis is only poorly understood. The Dis3 ribonuclease is a key component of the RNA-processing exosome complex. Previous isolat...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Hiroaki Murakami, Derek B Goto, Takashi Toda, Ee Sin Chen, Shiv I Grewal, Robert A Martienssen, Mitsuhiro Yanagida
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2007-03-01
Online Access:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0000317&type=printable