Biotransformation and transplacental transfer of the anti-viral remdesivir and predominant metabolite, GS-441524 in pregnant rats

Summary: Background: Remdesivir was the first prodrug approved to treat coronavirus disease 2019 (COVID-19) and has the potential to be used during pregnancy. However, it is not known whether remdesivir and its main metabolite, GS-441524 have the potential to cross the blood-placental barrier. We h...

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Bibliographic Details

Published in:	EBioMedicine
Main Authors:	Ling Yang, I-Hsin Lin, Lie-Chwen Lin, Jeffrey W. Dalley, Tung-Hu Tsai
Format:	Article
Language:	English
Published:	Elsevier 2022-07-01
Subjects:	Remdesivir GS-441524 Microdialysis Blood-placental barrier Pharmacokinetics
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352396422002766