Low fluid shear stress promotes chondrocyte proliferation and extracellular matrix secretion by downregulating mir-143-3p and activating the ERK5/KLF4 signaling pathway

Abstract Low fluid shear stress (FSS, ≤ 2 dyn/cm2) has been shown to exert protective effects on chondrocytes, but the underlying molecular mechanisms remain unclear. This study aimed to elucidate the mechanisms by which FSS promotes chondrocyte proliferation and extracellular matrix (ECM) stability...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Jun Zhao, Yayi Xia, Jinwen He
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-11-01
Subjects:	Fluid shear stress MiR-143-3p Extracellular signal-regulated kinase 5 Chondrocyte Proliferation
Online Access:	https://doi.org/10.1038/s41598-024-78676-w