Transient receptor potential channel TRPV4 mediates TGF-β1-induced differentiation of human ventricular fibroblasts

BACKGROUND: Cardiac fibroblasts (CFs) are principal extracellular matrix-producing cells. In response to injury, CFs transdifferentiate into myofibroblasts. Intracellular calcium (Ca2+) signaling, involved in fibroblast proliferation and differentiation, is activated in fibroblasts through transient...

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Bibliographic Details

Published in:	Cardiology Journal
Main Authors:	Min-Soo Ahn, Young Woo Eom, Ji-Eun Oh, Seung-Kuy Cha, Kyu Sang Park, Jung-Woo Son, Jun-Won Lee, Young Jin Youn, Sung Gyun Ahn, Jang-Young Kim, Seung-Hwan Lee, Junghan Yoon, Byung-Su Yoo
Format:	Article
Language:	English
Published:	Via Medica 2020-05-01
Subjects:	fibroblast myofibroblast transient receptor potential channels calcium
Online Access:	https://journals.viamedica.pl/cardiology_journal/article/view/62405