Intranasal delivery of DPSC-derived small extracellular vesicles-encased phloroglucinol attenuates non-motor and motor deficits and promotes neurogenesis in an in vivo rat model of Parkinson’s disease

Abstract Background Parkinson’s disease (PD) is characterized by dopaminergic (DA) neuron degeneration in the substantia nigra pars compacta (SNpc) driven by oxidative stress, inflammation, and impaired neurogenesis. Phloroglucinol, a polyphenolic antioxidant, has demonstrated neuroprotective effect...

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Bibliographic Details
Published in:Stem Cell Research & Therapy
Main Authors: Kallolika Mondal, Rituparna Ghanty, Anita Mahadevan, Girish Waghmare, Rashmi Santhoshkumar, Nandeesh BN, Indrani Datta
Format: Article
Language:English
Published: BMC 2025-10-01
Subjects:
Extracellular vesicles
Exosomes
Targeted drug-delivery vehicle
Encapsulation
MPTP chronic rat PD model
Substantia nigra par compacta
Online Access:https://doi.org/10.1186/s13287-025-04573-2

Internet

https://doi.org/10.1186/s13287-025-04573-2

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