A randomized phase II/III trial of rosuvastatin with neoadjuvant chemo-radiation in patients with locally advanced rectal cancer

AimStatins have been shown to improve the possibility of a pathological complete response (pCR) in patients with locally advanced rectal cancer when given in combination with neo-adjuvant chemo-radiation (NACTRT) in observational studies. The primary objective of this phase II randomized controlled...

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Bibliographic Details

Published in:	Frontiers in Oncology
Main Authors:	Prachi S. Patil, Avanish Saklani, Naveena A. N. Kumar, Ashwin De’Souza, Rahul Krishnatry, Snehal Khanvilkar, Mufaddal Kazi, Reena Engineer, Vikas Ostwal, Anant Ramaswamy, Munita Bal, Priya Ranganathan, Ekta Gupta, Sanjeev Galande
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-03-01
Subjects:	rosuvastatin pathological complete response neoadjuvant chemoradiation rectal cancer drug repurposing
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2025.1450602/full