Activation of PERK/eIF2α/ATF4 signaling inhibits ERα expression in breast cancer

Approximately 70–80% of breast cancers rely on estrogen receptor alpha (ERα) for growth. The unfolded protein response (UPR), a cellular response to endoplasmic reticulum stress (ERS), is an important process crucial for oncogenic transformation. The effect of ERS on ERα expression and signaling rem...

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出版年:	Neoplasia: An International Journal for Oncology Research
主要な著者:	Yuanli Wu, Gang Wang, Ruixue Yang, Duanfang Zhou, Qingjuan Chen, Qiuya Wu, Bo Chen, Lie Yuan, Na Qu, Hongmei Wang, Moustapha Hassan, Ying Zhao, Mingpu Liu, Zhengze Shen, Weiying Zhou
フォーマット:	論文
言語:	英語
出版事項:	Elsevier 2025-07-01
主題:	Breast cancer ESR1 ERα Endoplasmic reticulum stress Unfolded protein response ATF4
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S1476558625000442