PARP Inhibition Shifts Murine Myeloid Cells Toward a More Tolerogenic Profile In Vivo

The human Poly ADP-ribose Polymerase (PARP) family comprises 17 enzymes responsible for the transfer of ADP-ribose to proteins, forming poly- or mono-ADP-ribosylation. This post-translational modification regulates DNA repair and programmed cell death, processes affecting cancer biology. PARP inhibi...

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Bibliographic Details
Published in:Biomolecules
Main Authors: Jose R. Pittaluga-Villarreal, Casey M. Daniels, Tara Capece, Pauline R. Kaplan, Martin Meier-Schellersheim, Aleksandra Nita-Lazar
Format: Article
Language:English
Published: MDPI AG 2025-08-01
Subjects:
olaparib
PARP inhibitors
myeloid cells
dendritic cells
neutrophils
macrophages
Online Access:https://www.mdpi.com/2218-273X/15/8/1149

Internet

https://www.mdpi.com/2218-273X/15/8/1149

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