CNPY2 protects against ER stress and is expressed by corticostriatal neurons together with CTIP2 in a mouse model of Huntington’s disease

Canopy Homolog 2 (CNPY2) is an endoplasmic reticulum (ER) localized protein belonging to the CNPY gene family. We show here that CNPY2 is protective against ER stress induced by tunicamycin in neuronal cells. Overexpression of CNPY2 enhanced, while downregulation of CNPY2 using shRNA expression, red...

Full description

Bibliographic Details

Published in:	Frontiers in Molecular Neuroscience
Main Authors:	Miriana Scordino, Polina Stepanova, Vignesh Srinivasan, Dan Duc Pham, Ove Eriksson, Maciej Lalowski, Giuseppa Mudò, Valentina Di Liberto, Laura Korhonen, Merja H. Voutilainen, Dan Lindholm
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-09-01
Subjects:	UPR ER stress CNPY2 CTIP2 nerve cell viability Huntington’s disease
Online Access:	https://www.frontiersin.org/articles/10.3389/fnmol.2024.1473058/full