Human‐specific polymorphic pseudogenization of SIGLEC12 protects against advanced cancer progression

Abstract Compared with our closest living evolutionary cousins, humans appear unusually prone to develop carcinomas (cancers arising from epithelia). The SIGLEC12 gene, which encodes the Siglec‐XII protein expressed on epithelial cells, has several uniquely human features: a fixed homozygous missens...

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Bibliographic Details

Published in:	FASEB BioAdvances
Main Authors:	Shoib S Siddiqui, Michael Vaill, Raymond Do, Naazneen Khan, Andrea L Verhagen, Wu Zhang, Heinz‐Josef Lenz, Teresa L Johnson‐Pais, Robin J Leach, Gary Fraser, Charles Wang, Gen‐Sheng Feng, Nissi Varki, Ajit Varki
Format:	Article
Language:	English
Published:	Wiley 2021-02-01
Subjects:	advanced carcinoma dot blot immunohistochemistry pseudogenization SIGLEC12
Online Access:	https://doi.org/10.1096/fba.2020-00092