Water-soluble substituted chitosan derivatives as technology platform for inhalation delivery of siRNA

Despite research efforts full potential of siRNA-based therapeutics has not yet been fully realized due to a need for suitable, effective delivery formulations. Here, we examine a potential of a new class of water-soluble chitosans as siRNA platform for pulmonary delivery. The system is based on pip...

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Bibliographic Details

Published in:	Drug Delivery
Main Authors:	Victoria Capel, Driton Vllasaliu, Peter Watts, Philip A. Clarke, Dominic Luxton, Anna M. Grabowska, Giuseppe Mantovani, Snjezana Stolnik
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2018-01-01
Subjects:	chitosan sirna delivery sirna complex lung inhalation ivis imaging
Online Access:	http://dx.doi.org/10.1080/10717544.2018.1440668