Determination of Deamidation in Adjuvanted Vaccine Antigens through Isoaspartic Acid Quantification

Deamidation is a post-translational chemical modification that occurs within proteins and can be influenced by many factors, including temperature and pH. In vaccines, deamidation is considered undesirable as it may lead to changes in structure, function, stability, and immunogenicity. Detecting dea...

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Bibliographic Details
Published in:Vaccines
Main Authors: Manvi Hasija, Jian Ma, Bing Li, Nausheen Rahman, Kirsten A. Strahlendorf, Salvador Fernando Ausar
Format: Article
Language:English
Published: MDPI AG 2024-07-01
Subjects:
vaccine
stability
deamidation
formulation
isoaspartic acid
degradation
Online Access:https://www.mdpi.com/2076-393X/12/7/733

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https://www.mdpi.com/2076-393X/12/7/733

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