Fragment-Sized and Bidentate (Immuno)Proteasome Inhibitors Derived from Cysteine and Threonine Targeting Warheads

Constitutive- and immunoproteasomes are part of the ubiquitin–proteasome system (UPS), which is responsible for the protein homeostasis. Selective inhibition of the immunoproteasome offers opportunities for the treatment of numerous diseases, including inflammation, autoimmune diseases, and hematolo...

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Bibliographic Details

Published in:	Cells
Main Authors:	Levente Kollár, Martina Gobec, Matic Proj, Lara Smrdel, Damijan Knez, Tímea Imre, Ágnes Gömöry, László Petri, Péter Ábrányi-Balogh, Dorottya Csányi, György G. Ferenczy, Stanislav Gobec, Izidor Sosič, György M. Keserű
Format:	Article
Language:	English
Published:	MDPI AG 2021-12-01
Subjects:	immunoproteasome benzoxazole-2-carbonitriles bidentate covalent inhibitors fragments non-covalent recognition
Online Access:	https://www.mdpi.com/2073-4409/10/12/3431