Wee1 promotes cell proliferation and imatinib resistance in chronic myeloid leukemia via regulating DNA damage repair dependent on ATM-γH2AX-MDC1

Abstract Background The treatment of chronic myeloid leukemia (CML) is facing the dilemma of tyrosine kinase inhibitors (TKIs) resistance and disease recurrence. The dysfunctional DNA damage repair mechanism plays an essential role not only in the initiation and progression of hematological malignan...

全面介紹

書目詳細資料

發表在:	Cell Communication and Signaling
Main Authors:	Fanting Zeng, Yuhang Peng, Yuefeng Qin, Jianming Wang, Guoyun Jiang, Wenli Feng, Ying Yuan
格式:	Article
語言:	英语
出版:	BMC 2022-12-01
主題:	Chronic myeloid leukemia Wee1 DNA damage repair DNA damage response
在線閱讀:	https://doi.org/10.1186/s12964-022-01021-z