LAP2α orchestrates alternative lengthening of telomeres suppression through telomeric heterochromatin regulation with HDAC1: unveiling a potential therapeutic target

Abstract In response to the challenge of telomere attrition during DNA replication, cancer cells predominantly employ telomerase or, in 10–15% of cases, the alternative lengthening of telomeres (ALT). The intricate details of ALT, however, remain elusive. In this study, we unveil that the knockdown...

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Bibliographic Details

Published in:	Cell Death and Disease
Main Authors:	Bing Wang, Haomeng Kou, Yuwen Wang, Qi Zhang, Duo Jiang, Juan Wang, Ziqin Zhao, Yao Zhou, Miaomiao Zhang, Lei Sui, Mingfeng Zhao, Yancheng Liu, Yang Liu, Lei Shi, Feng Wang
Format:	Article
Language:	English
Published:	Nature Publishing Group 2024-10-01
Online Access:	https://doi.org/10.1038/s41419-024-07116-4