Ccr4-not regulates RNA polymerase I transcription and couples nutrient signaling to the control of ribosomal RNA biogenesis.

Ribosomal RNA synthesis is controlled by nutrient signaling through the mechanistic target of rapamycin complex 1 (mTORC1) pathway. mTORC1 regulates ribosomal RNA expression by affecting RNA Polymerase I (Pol I)-dependent transcription of the ribosomal DNA (rDNA) but the mechanisms involved remain o...

Full description

Bibliographic Details

Published in:	PLoS Genetics
Main Authors:	R Nicholas Laribee, Amira Hosni-Ahmed, Jason J Workman, Hongfeng Chen
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2015-03-01
Online Access:	http://europepmc.org/articles/PMC4376722?pdf=render