The Fusion Protein rFlaA:Betv1 Modulates DC Responses by a p38-MAPK and COX2-Dependent Secretion of PGE₂ from Epithelial Cells

Developing new adjuvants/vaccines and better understanding their mode-of-action is an important task. To specifically improve birch pollen allergy treatment, we designed a fusion protein consisting of major birch pollen allergen Betv1 conjugated to the TLR5-ligand flagellin (rFlaA:Betv1). This study...

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Bibliographic Details

Published in:	Cells
Main Authors:	Yen-Ju Lin, Adam Flaczyk, Sonja Wolfheimer, Alexandra Goretzki, Annette Jamin, Andrea Wangorsch, Stefan Vieths, Stephan Scheurer, Stefan Schülke
Format:	Article
Language:	English
Published:	MDPI AG 2021-12-01
Subjects:	flagellin Betv1 epithelial cells vaccine fusion protein
Online Access:	https://www.mdpi.com/2073-4409/10/12/3415