Generation of the ICGi019-B-1 and ICGi019-B-2 lines via correction of the p.Met659Ile (c.1977G>A) variant in MYH7 of patient-specific induced pluripotent stem cells using CRISPR/Cas9

The problem of interpretation of the genetic data from patients with inherited cardiovascular diseases still remains relevant. To date, the clinical significance of approximately 40 % of variants in genes associated with in herited cardiovascular diseases is uncertain, which requires new approaches...

Full description

Bibliographic Details

Published in:	Вавиловский журнал генетики и селекции
Main Authors:	A. E. Shulgina, S. V. Pavlova, J. M. Minina, S. M. Zakian, E. V. Dementyeva
Format:	Article
Language:	English
Published:	Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders 2025-06-01
Subjects:	hypertrophic cardiomyopathy variants of unknown significance induced pluripotent stem cells crispr/cas9
Online Access:	https://vavilov.elpub.ru/jour/article/view/4601