The evaluation of red blood cell folate and methotrexate levels during protocol M in childhood acute lymphoblastic leukemia

Abstract Background After High-Dose Methotrexate (HD-MTX), folinic acid rescue therapy (Leucovorin) is administered to reduce side effects in pediatric acute lymphoblastic leukemia (ALL) patients. Leucovorin and MTX are structural analogues, possibly competing for cellular transport and intracellula...

Full description

Bibliographic Details

Published in:	BMC Cancer
Main Authors:	N. Oosterom, M. Fiocco, R. Q. H. Kloos, I. M. van der Sluis, R. Pieters, B. D. van Zelst, D. E. C. Smith, M. M. van den Heuvel-Eibrink, R. de Jonge, S. G. Heil
Format:	Article
Language:	English
Published:	BMC 2020-09-01
Subjects:	Methotrexate Leucovorin Acute lymphoblastic leukemia Pediatric oncology
Online Access:	http://link.springer.com/article/10.1186/s12885-020-07422-y