IgG1 and IgG4 antibodies sample initial structure dependent local conformational states and exhibit non-identical Fab dynamics
Abstract We have investigated the dynamics of two $$\upgamma$$ γ -immunoglobulin molecules, IgG1 and IgG4, using long all atom molecular dynamics simulations. We first show that the de novo structures of IgG1 and IgG4 predicted using AlphaFold, with no interactions between the fragment crystallizabl...
| Published in: | Scientific Reports |
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| Main Authors: | , |
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-03-01
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| Online Access: | https://doi.org/10.1038/s41598-023-32067-9 |