mGluR5 Is Substitutable for mGluR1 in Cerebellar Purkinje Cells for Motor Coordination, Developmental Synapse Elimination, and Motor Learning

Group I metabotropic glutamate receptors (mGluRs) include mGluR1 and mGluR5, which are coupled to the Gq family of heterotrimeric G-proteins and readily activated by their selective agonist 3,5-dihydroxyphenilglycine (DHPG). mGluR1 and mGluR5 exhibit nearly complementary distributions spatially or t...

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Bibliographic Details

Published in:	Cells
Main Authors:	Maria Harbers, Harumi Nakao, Takaki Watanabe, Kyoko Matsuyama, Shoichi Tohyama, Kazuki Nakao, Yasushi Kishimoto, Masanobu Kano, Atsu Aiba
Format:	Article
Language:	English
Published:	MDPI AG 2022-06-01
Subjects:	Purkinje cells mGluR5 mGluR1 motor coordination synapse elimination eyeblink conditioning
Online Access:	https://www.mdpi.com/2073-4409/11/13/2004