Role of chitinase-3-like protein 1 in liver diseases: A comprehensive review

Chitinase-3-like protein 1 (CHI3L1) is part of the glycoside hydrolase family 18. Despite lacking enzymatic activity, its unique structure allows it to bind to ligands, altering its steric configuration to mediate cell proliferation, inflammation, fibrosis, and carcinogenesis. In liver disease, CHI3...

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Bibliographic Details

Published in:	Genes and Diseases
Main Authors:	Chao Tian, Shizhou Deng, Ming Yang, Baochen Bai, Lai Wei
Format:	Article
Language:	English
Published:	KeAi Communications Co., Ltd. 2025-11-01
Subjects:	Chitinase-3-like protein 1 Hepatic fibrosis Hepatocellular carcinoma Liver disease biomarker Non-alcoholic steatohepatitis Signaling pathways
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352304225001424