Mass Spectrometry Analysis of Newly Emerging Coronavirus HCoV-19 Spike Protein and Human ACE2 Reveals Camouflaging Glycans and Unique Post-Translational Modifications

The coronavirus disease 2019 (COVID-19) pandemic has led to worldwide efforts to understand the biological traits of the newly identified human coronavirus (HCoV-19) virus. In this mass spectrometry (MS)-based study, we reveal that out of 21 possible glycosites in the HCoV-19 spike protein (S protei...

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Bibliographic Details

Published in:	Engineering
Main Authors:	Zeyu Sun, Keyi Ren, Xing Zhang, Jinghua Chen, Zhengyi Jiang, Jing Jiang, Feiyang Ji, Xiaoxi Ouyang, Lanjuan Li
Format:	Article
Language:	English
Published:	Elsevier 2021-10-01
Subjects:	N-glycosylation COVID-19 Spike protein hACE2 Structure
Online Access:	http://www.sciencedirect.com/science/article/pii/S2095809920302344