Early Detection of the Pathogenetic Variants of Homologous Recombination Repair Genes in Prostate Cancer: Critical Analysis and Experimental Design

It has been shown that the pathogenic variants (PVs) of the DNA Damage Response (DDR) genes, whether of a germinal or somatic nature, represent a predictive biomarker of high sensitivity to treatment with inhibitors of the enzyme poly-ADP-ribose polymerase (PARP) in patients with hormone-resistant m...

Full description

Bibliographic Details

Published in:	Biology
Main Authors:	Irene Bottillo, Alessandro Sciarra, Giulio Bevilacqua, Alessandro Gentilucci, Beatrice Sciarra, Valerio Santarelli, Stefano Salciccia, Francesca Bacigalupo, Francesco Pastacaldi, Maria Pia Ciccone, Laura De Marchis, Daniele Santini, Fabio Massimo Magliocca, Elisabetta Merenda, Flavio Forte, Paola Grammatico
Format:	Article
Language:	English
Published:	MDPI AG 2025-01-01
Subjects:	prostate neoplasm BRCA gene DDR gene
Online Access:	https://www.mdpi.com/2079-7737/14/2/117