Three-dimensional mapping of tick-borne encephalitis virus distribution in the mouse brain using a newly engineered TurboGFP reporter virus

Tick-borne encephalitis virus (TBEV) is a neurotropic orthoflavivirus that invades the central nervous system, leading to severe neurological manifestations. In this study, we developed a reporter virus comprising TurboGFP-expressing TBEV (tGFP-TBEV) as a versatile tool for advancing TBEV research....

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Bibliographic Details

Published in:	Emerging Microbes and Infections
Main Authors:	Michaela Berankova, Simone Leoni, Jiri Holoubek, Jan Haviernik, Jiri Salat, Denis Grandgirard, Stephen L. Leib, Daniel Ruzek
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2025-12-01
Subjects:	TBEV reporter viruses neurotropism organotypic cerebellar slices light-sheet microscopy tissue clearing
Online Access:	https://www.tandfonline.com/doi/10.1080/22221751.2025.2542246