Concerted IL-25R and IL-4Rα signaling drive innate type 2 effector immunity for optimal helminth expulsion

Interleukin 25 (IL-25) is a major 'alarmin' cytokine, capable of initiating and amplifying the type immune response to helminth parasites. However, its role in the later effector phase of clearing chronic infection remains unclear. The helminth Heligmosomoides polygyrus establishes long-te...

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Bibliographic Details
Published in:eLife
Main Authors: Katherine A Smith, Stephan Löser, Fumi Varyani, Yvonne Harcus, Henry J McSorley, Andrew NJ McKenzie, Rick M Maizels
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-09-01
Subjects:
heligmosomoides polygyrus
cytokines
myeloid cells
Online Access:https://elifesciences.org/articles/38269

Internet

https://elifesciences.org/articles/38269

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