The Time-Dependent Role of Bisphosphonates on Atherosclerotic Plaque Calcification

Atherosclerotic plaque calcification directly contributes to the leading cause of morbidity and mortality by affecting plaque vulnerability and rupture risk. Small microcalcifications can increase plaque stress and promote rupture, whereas large calcifications can stabilize plaques. Drugs that targe...

Full description

Bibliographic Details
Published in:	Journal of Cardiovascular Development and Disease
Main Authors:	Amirala Bakhshian Nik, Hooi Hooi Ng, Manuel Garcia Russo, Francesco Iacoviello, Paul R. Shearing, Sergio Bertazzo, Joshua D. Hutcheson
Format:	Article
Language:	English
Published:	MDPI AG 2022-05-01
Subjects:	atherosclerotic plaque calcification calcification paradox bisphosphonates
Online Access:	https://www.mdpi.com/2308-3425/9/6/168

Similar Items

The Influence of Calcification Factors and Endothelial-Dysfunction Factors on the Development of Unstable Atherosclerotic Plaques
by: Yana V. Polonskaya, et al.
Published: (2020-12-01)

The Complex Mechanisms and the Potential Effects of Statins on Vascular Calcification: A Narrative Review
by: Nikolaos PE Kadoglou, et al.
Published: (2024-01-01)

Calcification in Atherosclerotic Plaque Vulnerability: Friend or Foe?
by: Xuan Shi, et al.
Published: (2020-02-01)

Preterm Infant with Generalized Arterial Calcification of Infancy Who Survived Due to Early Diagnosis and Appropriate Treatment with Bisphosphonates: A Case Report
by: Masato Tanaka, et al.
Published: (2024-09-01)

Considerations on the Development of Therapeutics in Vascular Calcification
by: Ana M. Valentin Cabrera, et al.
Published: (2025-05-01)

Comparative efficacy of sodium thiosulfate, bisphosphonates, and cinacalcet for the treatment of vascular calcification in patients with haemodialysis: a systematic review and network meta-analysis
by: Lei He, et al.
Published: (2024-01-01)

Nitrogen-containing bisphosphonate for vascular calcification: animal experiments, systematic review and meta-analysis
by: Wei Xu, et al.
Published: (2025-01-01)

EVALUATION OF CAROTID CALCIFICATIONS IN AMBULATORY DIALYSIS PATIENTS
by: Mircea Călin Țandrău, et al.
Published: (2019-12-01)

Biomarkers of vascular calcification: their relationship with diseases of the cardiovascular system and their importance in clinical practice
by: N. A. Maslatsov, et al.
Published: (2021-06-01)

Prevalence of carotid artery calcification in the 25-64-year population in a large city of the Siberian Federal District
by: V. S. Kaveshnikov, et al.
Published: (2025-07-01)

CT texture analysis of vertebrobasilar artery calcification to identify culprit plaques
by: Bo Liu, et al.
Published: (2024-05-01)

The Elusive Origin of Atherosclerotic Plaque Calcification
by: Emmanuelle Canet-Soulas, et al.
Published: (2021-03-01)

Breast arterial calcification and carotid arteries atherosclerotic load in women
by: I. V. Kim, et al.
Published: (2024-07-01)

Immobilized Bisphosphonates as Potential Inhibitors of Bioprosthetic Calcification: Effects on Various Xenogeneic Cardiovascular Tissues
by: Irina Y. Zhuravleva, et al.
Published: (2021-12-01)

Quantification of calcified particles in human valve tissue reveals asymmetry of calcific aortic valve disease development
by: Katsumi Yabusaki, et al.
Published: (2016-11-01)

Prevalence of Pathologic Findings in Panoramic Radiographs: Calcified Carotid Artery Atheroma
by: Jéssica Rodrigues da Silva Noll Gonçalves, et al.
Published: (2016-01-01)

Overlapping Genetic Background of Coronary Artery and Carotid/Femoral Atherosclerotic Calcification
by: Anita Hernyes, et al.
Published: (2021-03-01)

3D-Printed Coronary Plaques to Simulate High Calcification in the Coronary Arteries for Investigation of Blooming Artifacts
by: Zhonghua Sun, et al.
Published: (2021-09-01)

The Impact of Coronary Artery Calcification on Long-Term Cardiovascular Outcomes
by: Mitra Noémi, et al.
Published: (2021-03-01)

Factors associated with carotid artery calcification in the general working-age population
by: V. S. Kaveshnikov, et al.
Published: (2024-10-01)

A CASE OF OSTEOPOROSIS OF THE SPINE IN AN ELDERLY MALE WITH CALCIFIC AORTIC STENOSIS
by: N. Yu. Karpova, et al.
Published: (2014-07-01)

Calcifications sclérales séniles
by: abdelhamid khachane, et al.
Published: (2018-06-01)

Converging Mechanisms of Vascular and Cartilaginous Calcification
by: Simona R. Gheorghe, et al.
Published: (2024-07-01)

Role of Sortilin and Matrix Vesicles in Nϵ-Carboxymethyl-Lysine-Induced Diabetic Atherosclerotic Calcification
by: Jing L, et al.
Published: (2020-11-01)

In Vitro Models of Cardiovascular Calcification
by: Andrea Tóth, et al.
Published: (2024-09-01)

The crosstalk between vascular MSCs and inflammatory mediators determines the pro-calcific remodelling of human atherosclerotic aneurysm
by: Carmen Ciavarella, et al.
Published: (2017-04-01)

METHODS FOR CELLULAR AND MOLECULAR COMPOUND OF ATHEROSCLEROTIC PLAQUES ASSESSMENT: LITERARY REVIEW
by: Yu. V. Saranchina, et al.
Published: (2017-10-01)

Visualization of Atherosclerotic Plaques Paired with Joheksol 350 (Omnipaque)
by: Piotr Wańczura, et al.
Published: (2025-02-01)

Cardiac Calcifications: Phenotypes, Mechanisms, Clinical and Prognostic Implications
by: Francesco Vieceli Dalla Sega, et al.
Published: (2022-03-01)

High relative amount of nodular calcification in femoral plaques is associated with milder lower extremity arterial disease
by: Mae Azeez, et al.
Published: (2022-12-01)

Classification of carotid atherosclerotic plaque components using T2 mapping technique from magnetic resonance imaging
by: Sranut Chunpenmongkol, et al.
Published: (2014-01-01)

Association between chlamydia pneumoniae infection and carotid atherosclerotic plaques
by: Fereshteh Ashtari, et al.
Published: (2007-08-01)

Protein S on the surface of plasma lipoproteins: a potential mechanism for protein S delivery to the atherosclerotic plaques?
by: Marcello Baroni, et al.
Published: (2022-10-01)

A Case of Extensive Myocardial Calcification
by: Rizwan Yusuf, et al.
Published: (2022-11-01)

CALCIFIC AORTIC STENOSIS AND OSTEOPOROSIS: GENERAL MECHANISMS AND PERSPECTIVES OF PHARMACOLOGICAL CORRECTION
by: N. Yu. Karpova, et al.
Published: (2014-07-01)

CALCIFIC AORTIC STENOSIS AND OSTEOPOROSIS: GENERAL MECHANISMS AND PERSPECTIVES OF PHARMACOLOGICAL CORRECTION
by: N. Yu. Karpova, et al.
Published: (2014-07-01)

Plaque regression and plaque stabilisation in cardiovascular diseases
by: Tarun Dave, et al.
Published: (2013-01-01)

An Imaging Review on Urinary Tract Calcifications
by: Sushil. G. Kachewar, et al.
Published: (2013-04-01)

ATP Supply May Contribute to Light-Enhanced Calcification in Corals More Than Abiotic Mechanisms
by: Giovanni Galli, et al.
Published: (2018-03-01)

A Proteomic Study of Atherosclerotic Plaques in Men with Coronary Atherosclerosis
by: Ekaterina M. Stakhneva, et al.
Published: (2019-11-01)