Rejuvenating aged microglia by p16ink4a-siRNA-loaded nanoparticles increases amyloid-β clearance in animal models of Alzheimer’s disease

Abstract Age-dependent accumulation of amyloid plaques in patients with sporadic Alzheimer’s disease (AD) is associated with reduced amyloid clearance. Older microglia have a reduced ability to phagocytose amyloid, so phagocytosis of amyloid plaques by microglia could be regulated to prevent amyloid...

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Bibliographic Details

Published in:	Molecular Neurodegeneration
Main Authors:	Hyo Jung Shin, In Soo Kim, Seung Gyu Choi, Kayoung Lee, Hyewon Park, Juhee Shin, Dayoung Kim, Jaewon Beom, Yoon Young Yi, Deepak Prasad Gupta, Gyun Jee Song, Won-Suk Chung, C. Justin Lee, Dong Woon Kim
Format:	Article
Language:	English
Published:	BMC 2024-03-01
Subjects:	Alzheimer’s disease Microglia senescence Phagocytosis p16ink4a Cell cycle
Online Access:	https://doi.org/10.1186/s13024-024-00715-x