Fusion of Reprogramming Factors Alters the Trajectory of Somatic Lineage Conversion

Summary: Simultaneous expression of Oct4, Klf4, Sox2, and cMyc induces pluripotency in somatic cells (iPSCs). Replacing Oct4 with the neuro-specific factor Brn4 leads to transdifferentiation of fibroblasts into induced neural stem cells (iNSCs). However, Brn4 was recently found to induce transient a...

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Bibliographic Details

Published in:	Cell Reports
Main Authors:	Sergiy Velychko, Kyuree Kang, Sung Min Kim, Tae Hwan Kwak, Kee-Pyo Kim, Chanhyeok Park, Kwonho Hong, ChiHye Chung, Jung Keun Hyun, Caitlin M. MacCarthy, Guangming Wu, Hans R. Schöler, Dong Wook Han
Format:	Article
Language:	English
Published:	Elsevier 2019-04-01
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124719303390