RNA polymerase II primes Polycomb‐repressed developmental genes throughout terminal neuronal differentiation

Abstract Polycomb repression in mouse embryonic stem cells (ESCs) is tightly associated with promoter co‐occupancy of RNA polymerase II (RNAPII) which is thought to prime genes for activation during early development. However, it is unknown whether RNAPII poising is a general feature of Polycomb rep...

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Bibliographic Details

Published in:	Molecular Systems Biology
Main Authors:	Carmelo Ferrai, Elena Torlai Triglia, Jessica R Risner‐Janiczek, Tiago Rito, Owen JL Rackham, Inês de Santiago, Alexander Kukalev, Mario Nicodemi, Altuna Akalin, Meng Li, Mark A Ungless, Ana Pombo
Format:	Article
Language:	English
Published:	Springer Nature 2017-10-01
Subjects:	cell plasticity chromatin bivalency gene regulation RNA polymerase II transcriptional poising
Online Access:	https://doi.org/10.15252/msb.20177754