Mitotic Phosphorylation of TREX1 C Terminus Disrupts TREX1 Regulation of the Oligosaccharyltransferase Complex

TREX1 mutations are associated with several autoimmune and inflammatory diseases. The N-terminal DNase domain of TREX1 is important for preventing self-DNA from activating the interferon response. The C terminus of TREX1 is required for ER localization and regulation of oligosacchariyltransferase (O...

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Bibliographic Details

Published in:	Cell Reports
Main Authors:	Martin Kucej, Charles S. Fermaintt, Kun Yang, Ricardo A. Irizarry-Caro, Nan Yan
Format:	Article
Language:	English
Published:	Elsevier 2017-03-01
Subjects:	TREX1 cell cycle autoimmune disease DNase
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124717302498