Biophysical and pharmacokinetic characterization of a small-molecule inhibitor of RUNX1/ETO tetramerization with anti-leukemic effects

Abstract Acute myeloid leukemia (AML) is a malignant disease of immature myeloid cells and the most prevalent acute leukemia among adults. The oncogenic homo-tetrameric fusion protein RUNX1/ETO results from the chromosomal translocation t(8;21) and is found in AML patients. The nervy homology region...

Full description

Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Mohanraj Gopalswamy, Tobias Kroeger, David Bickel, Benedikt Frieg, Shahina Akter, Stephan Schott-Verdugo, Aldino Viegas, Thomas Pauly, Manuela Mayer, Julia Przibilla, Jens Reiners, Luitgard Nagel-Steger, Sander H. J. Smits, Georg Groth, Manuel Etzkorn, Holger Gohlke
Format:	Article
Language:	English
Published:	Nature Portfolio 2022-08-01
Online Access:	https://doi.org/10.1038/s41598-022-17913-6