CXCR4 blockade reduces the severity of murine heart allograft rejection by plasmacytoid dendritic cell-mediated immune regulation

Abstract Allograft-specific regulatory T cells (Treg cells) are crucial for long-term graft acceptance after transplantation. Although adoptive Treg cell transfer has been proposed, major challenges include graft-specificity and stability. Thus, there is an unmet need for the direct induction of gra...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Jian Fu, Christian H. K. Lehmann, Xinning Wang, Mandy Wahlbuhl, Ida Allabauer, Benjamin Wilde, Lukas Amon, Sebastian Dolff, Robert Cesnjevar, Andreas Kribben, Joachim Woelfle, Wolfgang Rascher, Peter F. Hoyer, Diana Dudziak, Oliver Witzke, André Hoerning
Format:	Article
Language:	English
Published:	Nature Portfolio 2021-12-01
Online Access:	https://doi.org/10.1038/s41598-021-03115-z