A dual fluorescence-based reporter assay for real-time determination of siRNA- and antisense oligonucleotide-mediated knockdown

In recent years, many tools have been developed for targeted treatments of cancer or rare diseases including nucleic acid (NA)-based therapeutics. One of the developmental caveats is the assessment of their functionality in vivo. We therefore developed a sensitive dual fluorescence-based FluoroDetec...

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发表在:	Molecular Therapy: Nucleic Acids
Main Authors:	Felix Heß, Margarete Odenthal, Elena Wasserburger-Zichel, Christina Grimm, Michal R. Schweiger
格式:	文件
语言:	英语
出版:	Elsevier 2025-09-01
主题:	MT: Oligonucleotides: Diagnostics and Biosensors small interfering RNA antisense oligonucleotide HSat3 fluorescence assay FluoroDetect
在线阅读:	http://www.sciencedirect.com/science/article/pii/S2162253125001854