A GelMA/polydopamine hydrogel with PTH and osteogenically stimulated alveolar mucosa-derived stem cells promotes bone regeneration in MRONJ-affected wounds

Abstract Background Medication-related osteonecrosis of the jaw (MRONJ) is a serious complication in patients taking bisphosphonates. This study aimed at developing a mesenchymal stem cell-based strategy to reduce the incidence of MRONJ and recover regeneration capability of MRONJ-affected wounds by...

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Bibliographic Details

Published in:	Stem Cell Research & Therapy
Main Authors:	Che-Chang Tu, Ming-Hsu Chen, Guan-Yu Lan, Yu-Ting Lin, Yu-Tse Lin, Wei-Chiu Tai, Jiashing Yu, Po-Chun Chang
Format:	Article
Language:	English
Published:	BMC 2025-09-01
Subjects:	Mesenchymal stem cell Bisphosphonate-associated osteonecrosis of the jaw MicroRNAs Wound healing Polydopamine Parathyroid hormone
Online Access:	https://doi.org/10.1186/s13287-025-04655-1