Antitumor activity of dual blockade of PD-L1 and MEK in NSCLC patients derived three-dimensional spheroid cultures

Abstract Background Anti-PD-1/PD-L1 drugs are effective as monotherapy in a proportion of NSCLC patients and there is a strong rationale for combining them with targeted therapy. Inhibition of MAPK pathway may have pleiotropic effects on the microenvironment. This work investigates the efficacy of c...

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Bibliographic Details

Published in:	Journal of Experimental & Clinical Cancer Research
Main Authors:	Carminia Maria Della Corte, Giusi Barra, Vincenza Ciaramella, Raimondo Di Liello, Giovanni Vicidomini, Silvia Zappavigna, Amalia Luce, Marianna Abate, Alfonso Fiorelli, Michele Caraglia, Mario Santini, Erika Martinelli, Teresa Troiani, Fortunato Ciardiello, Floriana Morgillo
Format:	Article
Language:	English
Published:	BMC 2019-06-01
Subjects:	MEK PD-L1 Lung cancer Organoid cultures
Online Access:	http://link.springer.com/article/10.1186/s13046-019-1257-1